Continuous positive airway pressure may affect daily body clock signals in people with obstructive sleep apnea

A significant increase in PER1 expression was observed in the morning after one-night continuous positive airway pressure treatment (p = 0.005).

• PER1 protein levels decreased in the morning after CPAP compared to the morning after diagnostic polysomnography (p = 0.035).
• CLOCK protein levels increased significantly in the morning after CPAP compared to the morning after polysomnography (p = 0.049).
• CLOCK levels also showed an increase in the morning after CPAP compared to the evening before treatment (p = 0.006).
• Changes in CLOCK levels were more pronounced after CPAP than between the morning and evening measurements before treatment (p = 0.012).
• Results suggest that short-term effective CPAP treatment may reverse disruptions in circadian clock signaling in obstructive sleep apnea.

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