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Assessment of continuous positive airway pressure effect on the circadian clock signaling pathway in obstructive sleep apnea patients
Continuous positive airway pressure may affect daily body clock signals in people with obstructive sleep apnea
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Abstract
A significant increase in PER1 expression was observed in the morning after one-night continuous positive airway pressure treatment (p = 0.005).
- PER1 protein levels decreased in the morning after CPAP compared to the morning after diagnostic polysomnography (p = 0.035).
- CLOCK protein levels increased significantly in the morning after CPAP compared to the morning after polysomnography (p = 0.049).
- CLOCK levels also showed an increase in the morning after CPAP compared to the evening before treatment (p = 0.006).
- Changes in CLOCK levels were more pronounced after CPAP than between the morning and evening measurements before treatment (p = 0.012).
- Results suggest that short-term effective CPAP treatment may reverse disruptions in circadian clock signaling in .
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Key numbers
95.6%
Reduction in AHI
AHI reduction observed after one night of CPAP treatment.
p = 0.005
Increase in PER1 Expression
PER1 expression increased in the morning after CPAP compared to evening before.
p = 0.006
Increase in CLOCK Protein Level
CLOCK protein level increased in the morning after CPAP treatment.