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Continuous positive airway pressure may affect daily body clock signals in people with obstructive sleep apnea
Updated
Abstract
A significant increase in PER1 expression was observed in the morning after one-night continuous positive airway pressure treatment (p = 0.005).
- PER1 protein levels decreased in the morning after CPAP compared to the morning after diagnostic polysomnography (p = 0.035).
- CLOCK protein levels increased significantly in the morning after CPAP compared to the morning after polysomnography (p = 0.049).
- CLOCK levels also showed an increase in the morning after CPAP compared to the evening before treatment (p = 0.006).
- Changes in CLOCK levels were more pronounced after CPAP than between the morning and evening measurements before treatment (p = 0.012).
- Results suggest that short-term effective CPAP treatment may reverse disruptions in circadian clock signaling in .
Simplified
Key numbers
95.6%
Reduction in AHI
AHI reduction observed after one night of CPAP treatment.
p = 0.005
Increase in PER1 Expression
PER1 expression increased in the morning after CPAP compared to evening before.
p = 0.006
Increase in CLOCK Protein Level
CLOCK protein level increased in the morning after CPAP treatment.