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Exploring differences in signaling pathways of the circadian clock and neuromodulators in obstructive sleep apnea
Differences in body clock signals and brain chemical activity in obstructive sleep apnea
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Abstract
In a study of 166 patients and 64 controls, BDNF expression was positively correlated with multiple circadian rhythm genes in the OSA group.
- The expression of circadian rhythm genes BMAL1, CLOCK, CRY1, PER1, NPAS2, NR1D1, and HIF-1β was positively associated with BDNF in OSA patients.
- In the control group, only PER1 mRNA showed a correlation with BDNF expression.
- NF-κβ expression correlated positively with several circadian rhythm genes in both OSA patients and controls.
- HIF-1α and HIF-1β mRNA expressions were positively correlated with circadian rhythm genes regardless of OSA presence.
- These findings suggest complex interactions among circadian rhythm genes, , and transcription factors in obstructive sleep apnea.
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Key numbers
86.4%
Higher Male Frequency
Percentage of males in the group compared to controls.
31.6 kg/m²
Greater BMI
Average body mass index in patients vs. 27.2 kg/m² in controls.
R = 0.326
Positive Gene Correlation
Correlation coefficient between PER1 and BDNF in patients.