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Common alterations to astrocytes across neurodegenerative disorders
Shared changes in brain support cells across different neurodegenerative diseases
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Abstract
Common alterations in astrocyte state are observed across multiple neurodegenerative disorders.
- Neuroinflammation is a shared alteration in astrocytes across Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, and frontotemporal lobe degeneration.
- Immune pathways are upregulated in astrocytes, which may exacerbate neurodegeneration.
- Dysregulated expression of factors that promote synapse formation could lead to synaptic loss.
- Compromised metabolic support from astrocytes may affect the stability of neurons.
- Increased responses to cellular stress in astrocytes may act as a protective mechanism against pathology.
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