Study setup and starting details of a phase 3 trial testing the oral drug orforglipron for high blood pressure

Up to three-quarters of primary hypertension is linked to excess body fat.

• Incretin-based therapies may reduce blood pressure based on clinical trial findings.
• No previous trials have focused on blood pressure as the primary outcome for treating hypertension with incretin-based therapies.
• Current evidence suggests a potential role of incretin-based therapies in managing hypertension.

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