Baseline and changes in serum uric acid independently predict 11-year incidence of metabolic syndrome among community-dwelling women

Feb 21, 2018Journal of endocrinological investigation

Uric acid levels and their changes predict 11-year risk of metabolic syndrome in women living in the community

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Of 407 women studied, 20.4% had metabolic syndrome (MetS) at baseline, increasing to 46.7% at follow-up.

Baseline and changes in serum uric acid (SUA) levels are independently associated with the number of MetS components over 11 years.
The odds ratios for incident MetS increased across tertiles of baseline SUA and changes in SUA, suggesting a dose-response relationship.
Significant associations for incident MetS were found primarily in women aged 55 years or older, those with declining kidney function, and those without baseline MetS.
The combined effect of elevated baseline and changes in SUA levels serves as a significant predictor for the accumulation of MetS components.

AI simplified

INTRODUCTION: Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. In women, increased serum uric acid (SUA) levels are associated with MetS and its components. However, whether baseline and changes in SUA predict incidence of MetS and its components remains unclear.

METHODS: The subjects comprised 407 women aged 71 ± 8 years from a rural village. We have identified participants who underwent a similar examination 11 years ago, and examined the relationship between baseline and changes in SUA, and MetS based on the modified criteria of the National Cholesterol Education Program's Adult Treatment Panel (NCEP-ATP) III report.

RESULTS: Of these subjects, 83 (20.4%) women at baseline and 190 (46.7%) women at follow-up had MetS. Multiple linear regression analysis was performed to evaluate the contribution of each confounding factor for MetS; both baseline and changes in SUA as well as history of cardiovascular disease, low-density lipoprotein cholesterol, and estimated glomerular filtration ratio (eGFR) were independently and significantly associated with the number of MetS components during an 11-year follow-up. The adjusted odds ratios (ORs) (95% confidence interval) for incident MetS across tertiles of baseline SUA and changes in SUA were 1.00, 1.47 (0.82-2.65), and 3.11 (1.66-5.83), and 1.00, 1.88 (1.03-3.40), and 2.49 (1.38-4.47), respectively. In addition, the combined effect between increased baseline and changes in SUA was also a significant and independent determinant for the accumulation of MetS components (F = 20.29, p < 0.001). The ORs for incident MetS were significant only in subjects with age ≥ 55 years, decline in eGFR, and no baseline MetS.

CONCLUSIONS: These results suggested that combined assessment of baseline and changes in SUA levels provides increased information for incident MetS, independent of other confounding factors in community-dwelling women.

Full Text

Full text is available at the source.

View full text (HTML) ↗View full text (PDF) ↗

Baseline and changes in serum uric acid independently predict 11-year incidence of metabolic syndrome among community-dwelling women

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief