Serum uric acid is associated with incident metabolic syndrome independent of body shape index and body roundness index in healthy individuals

Sep 14, 2021Nutrition, metabolism, and cardiovascular diseases : NMCD

Blood uric acid levels linked to new cases of metabolic syndrome regardless of body shape in healthy people

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

The incidence rate of metabolic syndrome (MetS) was 9.8% among 6221 healthy individuals studied.

Hyperuricemia was associated with a higher incidence of MetS (17.2% vs. 9.6%, P < 0.001) compared to individuals with normal uric acid levels.
Serum uric acid (SUA) levels showed a significant association with the incidence of MetS after adjusting for body mass index (BMI).
Body roundness index (BRI) and body shape index (BSI) were also significantly associated with incident MetS, although BSI lost its significance in further analyses.
BMI and BRI were identified as independent predictors of incident MetS.
Various thresholds of elevated SUA levels remained linked to the incidence of MetS in sensitivity analyses.

AI simplified

BACKGROUND AND AIMS: Elevated serum uric acid (SUA) levels, body shape index (BSI) and body roundness index (BRI) were associated with incident metabolic syndrome (MetS). We aimed to investigate the relationship among the SUA level, BSI, and BRI on the incidence of MetS.

METHODS AND RESULTS: We retrospectively included 6221 healthy individuals from annual health exams at our hospital between 2016/1/1 and 2016/12/31. We defined hyperuricemia as SUA levels greater than 7 mg/dl in men and 6 mg/dl in women and MetS according to the contemporary definition. The study cohort included 6221 healthy individuals with an overall incidence rate of MetS of 9.8%. Compared with the normouricemic group, the hyperuricemic group had a greater incidence of MetS (17.2% vs. 9.6%, P < 0.001). After full adjustment for confounders, the SUA level was significantly associated with incident MetS in addition to body mass index (BMI) (adjusted OR [aOR]: 1.161, 95% CI: 1.071-1.259, P < 0.001), BRI (aOR: 1.196, 95% CI: 1.104-1.296, P < 0.001), and BSI (aOR: 1.297, 95% CI: 1.200-1.403, P < 0.001). Regarding the anthropometric indices, BMI and BRI were independent predictors of incident MetS, but the BSI lost its significant association in multivariate logistic regression analyses. In sensitivity analyses, various thresholds of elevated SUA levels remained associated with incident MetS.

CONCLUSION: We showed a dose-response effect of SUA on incident MetS independent of BMI, BRI and BSI in healthy individuals. Future studies can use SUA levels to stratify cardiometabolic risk in healthy individuals.

CLINICAL TRIALS: ClinicalTrials.gov with the identification number NCT03473951.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Serum uric acid is associated with incident metabolic syndrome independent of body shape index and body roundness index in healthy individuals

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief