In a study of 13,057 subjects, increasing (SUA) levels may protect against the development of (MetS).
Higher percent changes in SUA levels are associated with lower hazard ratios for incident MetS in both males and females.
In males, hazard ratios for developing MetS in the second, third, and fourth quartiles of SUA change were 1.055, 0.927, and 0.807, respectively.
In females, corresponding hazard ratios were 1.000, 0.744, and 0.684.
Each one-standard deviation increase in percent change in SUA levels was associated with a hazard ratio of 0.944 in males and 0.851 in females for incident MetS.
These findings suggest that increasing SUA levels could have a protective effect against MetS.
Simplified
BACKGROUND: It has not been determined whether changes in (SUA) level are associated with incident (MetS). The aim of the current study was to investigate the relationship between changes in SUA level and development of MetS in a large number of subjects.
METHODS: In total, 13,057 subjects participating in a medical health check-up program without a diagnosis of MetS at baseline were enrolled. Cox proportional hazards models were used to test the independent association of percent changes in SUA level with development of MetS.
RESULTS: After adjustment for age, systolic blood pressure, body mass index, fat-free mass (%), estimated glomerular filtration rate, smoking status, fasting glucose, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and baseline SUA levels, the hazard ratios (HRs) (95% confidence intervals [CIs]) for incident MetS in the second, third, and fourth quartiles compared to the first quartile of percent change in SUA level were 1.055 (0.936 to 1.190), 0.927 (0.818 to 1.050), and 0.807 (0.707 to 0.922) in male (for trend <0.001) and 1.000 (0.843 to 1.186), 0.744 (0.615 to 0.900), and 0.684 (0.557 to 0.840) in female (for trend <0.001), respectively. As a continuous variable in the fully-adjusted model, each one-standard deviation increase in percent change in SUA level was associated with an HR (95% CI) for incident MetS of 0.944 (0.906 to 0.982) in male (=0.005) and 0.851 (0.801 to 0.905) in female (<0.001). P P P P
CONCLUSION: The current study demonstrated that increasing SUA level independently protected against the development of MetS, suggesting a possible role of SUA as an antioxidant in the pathogenesis of incident MetS.
Key numbers
0.851
Decrease in Risk of (Female)
Hazard ratio for incident in females with increased levels.
0.804
Decrease in Risk of (Male)
Hazard ratio for incident in males in the fourth quartile of change.
Full Text
We can’t show the full text here under this license.
