How a specific BDNF gene region may help ketamine provide protective effects

Disruption of the BDNF exon VI promoter may affect the prophylactic effects of (R,S)-ketamine.

• BDNF is known to be involved in the synthesis of proteins that support neuron health and function.
• The role of BDNF in the antidepressant effects of (R,S)-ketamine has been established, but its involvement in preventive effects is unclear.
• The study utilized BDNF-e6 mice with a specific disruption in BDNF production.
• Testing aimed to determine if the altered BDNF expression impacts the preventive capabilities of (R,S)-ketamine.

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