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Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe−/− mice
Berberine raises helpful gut bacteria and reduces artery disease caused by high-fat diet in mice lacking Apoe
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Abstract
Berberine treatment significantly reduced atherosclerosis in high-fat diet-fed mice.
- An increase in the abundance of Akkermansia bacteria was observed in HFD-fed mice treated with berberine.
- Berberine decreased metabolic endotoxemia induced by a high-fat diet.
- Treatment with berberine lowered the expression of proinflammatory cytokines and chemokines in arterial and intestinal tissues.
- Berberine enhanced the expression of proteins that form tight junctions and increased the thickness of the colonic mucus layer.
- These changes suggest a restoration of gut barrier integrity associated with berberine treatment.
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