Ginkgolide B treatment regulated intestinal flora to improve high-fat diet induced atherosclerosis in ApoE−/− mice

Dec 19, 2020Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ginkgolide B improves artery disease caused by a high-fat diet by changing gut bacteria in mice lacking ApoE

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Ginkgolide B (GB) treatment reduced atherosclerotic plaque formation in high fat diet-induced ApoE mice.

GB treatment decreased dyslipidemia and inflammation associated with atherosclerosis.
Gut barrier dysfunction was improved following GB administration.
Changes in gut microbiota included an increased abundance of Bacteroides and a decreased abundance of Helicobacter.
Decreased levels of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) were linked to alterations in gut microbial composition.
The findings suggest a potential therapeutic role for GB in manipulating gut microbiota to combat atherosclerosis.

AI simplified

Intestinal flora plays a major role in cardiovascular diseases, like atherosclerosis (AS). Ginkgolide B (GB), a natural substance extracted from Ginkgo biloba L., is recently acknowledged as a potential therapeutic drug of AS. However, the underlying mechanism of GB is not fully clear. Thus, we evaluated whether the antiatherosclerotic effect of GB was related to alterations in gut microbial structure and if so, whether specific bacterial taxa contributed to the beneficial effects of GB. We constructed a high fat diet (HFD)-induced ApoEmice model to explore the antiatherosclerotic effects of GB. The effects of GB on lipid metabolism, hypoglycemia, inflammation and gut barrier integrity were also investigated. Then HFD inventories and high throughput sequencing of the V3-V4 region of the bacterial 16S ribosomal RNA gene were used to characterize how GB modulated gut microbiome composition. We found that HFD-induced dyslipidemia, inflammation, increased atherosclerotic plaque and gut barrier dysfunction were reduced by GB treatment. Moreover, GB treatment obviously inhibited the mRNA level and protein expression of FMO3, and then decreased the concentrations of TMA and TMAO, which was related to changes of gut microbiota in HFD-fed mice. Modulation of gut microbiota, specifically the increased abundance of Bacteroides and decreased abundance of Helicobacter, might contribute to the antiatherosclerotic effects of GB. Our findings first support the therapeutic value of GB on gut microbiota manipulation in treating AS, which still need to further study. -/-

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Ginkgolide B treatment regulated intestinal flora to improve high-fat diet induced atherosclerosis in ApoE−/− mice

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief