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Berberine ameliorates vascular dysfunction by downregulating TMAO-endoplasmic reticulum stress pathway via gut microbiota in hypertension
Berberine improves blood vessel problems in high blood pressure by reducing harmful gut bacteria-related stress
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Abstract
Plasma TMAO levels were significantly elevated in 86 hypertensive patients compared to 46 normotensive controls.
- Elevated TMAO levels were negatively correlated with vascular function in hypertensive patients.
- TMAO was found to activate stress response pathways that can lead to endothelial cell dysfunction and death.
- Berberine treatment for 4 weeks reduced TMAO-induced vascular dysfunction and stress response activation in hypertensive mice.
- In 15 hypertensive patients, BBR treatment reduced plasma TMAO levels by 8.8% and 16.7% at months 1 and 3, respectively.
- BBR improved vascular function and lowered blood pressure in hypertensive patients and mice.
- BBR altered gut bacterial composition and inhibited the production of TMAO precursors by affecting specific gut bacteria.
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