Influence of beta-blockers on the myocardial mRNA expressions of circadian clock- and metabolism-related genes

Feb 12, 2013Journal of the American Society of Hypertension : JASH

Beta-blockers’ effects on heart gene activity related to daily rhythms and metabolism

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Abstract

Beta-blockers propranolol and atenolol increased ATP content in heart tissue throughout 24 hours.

  • The beta-blockers suppressed mRNA expressions of the clock genes Bmal1 and E4BP4 in heart tissue.
  • No changes were observed in the mRNA expressions of these clock genes in the suprachiasmatic nucleus.
  • Lactate dehydrogenase a and pyruvate dehydrogenase kinase 4 mRNA expressions in the heart were also suppressed by the beta-blockers.
  • Propranolol and atenolol did not significantly differ in their effects on heart tissue.
  • The influences of beta-blockers on heart metabolism may be independent of their lipid solubility.

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