Effect of phase delay lighting rotation schedule on daily expression of per2, bmal1, rev-erbα, pparα, and pdk4 genes in the heart and liver of Wistar rats

Clock gene expression in the heart and liver of shifted rats was rhythmic and phase delayed by 8-9 hours compared to control.

• Frequent shifts of the light:dark cycle may disrupt circadian rhythms and metabolic functions.
• The nuclear receptor PPARα appears to link circadian clocks with metabolism.
• Key clock genes rev-erbα, pparα, and pdk4 were analyzed in the liver and heart.
• Metabolic gene expression was more affected in the liver than in the heart.
• The study suggests that shifting light cycles could impair lipid metabolism regulation.

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