Bioengineering tools for boosting organoid therapies

Organoids may improve regenerative medicine but currently face limitations such as lack of internal vasculature and small size.

• Organoids are three-dimensional structures that mimic specific organs.
• Current organoid technology has advanced but still lacks essential features for effective regenerative medicine.
• Limitations include inadequate internal blood vessel systems, restricted functionality, and small size compared to real organs.
• Reliance on mouse tumor-derived materials for organoid culture raises safety concerns for clinical use.
• Engineering strategies and alternative biocompatible materials could enhance the applicability of organoids in medicine.
• Progress in organoid transplantation shows potential for restoring function in various organs.

Simplified