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Association of biological age acceleration with mortality in adults with diabetes or prediabetes: a mediating role of physical activity
Faster biological aging linked to higher death risk in adults with diabetes or prediabetes, partly through physical activity levels
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Abstract
Participants in the high tertile of acceleration had a 35% higher risk of all-cause mortality compared to those in the low tertile.
- 1,445 deaths occurred over a median follow-up period of 94 months among 7,337 participants.
- Biological age acceleration was assessed using the .
- Engaging in β₯ 600 of physical activity was associated with a lower risk of all-cause mortality.
- Physical activity accounted for 17.53% of the association between biological age acceleration and all-cause mortality.
- Similar associations were observed for cardiovascular mortality.
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Key numbers
1.35
Increase in Mortality Risk
HR for all-cause mortality in high vs. low tertiles.
0.86
Lower Mortality Risk with
HR for all-cause mortality with β₯ 600 vs. < 600.
17.53%
Proportion of
Percentage of the association explained by .