Understanding the significance of biological clock and its impact on cancer incidence

🥉 Top 5% JournalDec 15, 2021Cancer letters

How the Body's Internal Clock May Affect Cancer Risk

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Circadian disruptions are associated with various diseases, including cancer.

Perturbations in circadian rhythms may affect energy balance and lead to changes in the cell cycle.
Disruption of the circadian clock is linked to dysregulation of chromatin remodeling.
A mechanistic understanding of how circadian disruption enhances cancer risk remains limited.
The review discusses the role of the circadian clock in tumor development and the mechanisms involved.
Advances in chronotherapy for cancer treatment are highlighted.

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The circadian clock is an essential timekeeper that controls, for humans, the daily rhythm of biochemical, physiological, and behavioral functions. Irregular performance or disruption in circadian rhythms results in various diseases, including cancer. As a factor in cancer development, perturbations in circadian rhythms can affect circadian homeostasis in energy balance, lead to alterations in the cell cycle, and cause dysregulation of chromatin remodeling. However, knowledge gaps remain in our understanding of the relationship between the circadian clock and cancer. Therefore, a mechanistic understanding by which circadian disruption enhances cancer risk is needed. This review article outlines the importance of the circadian clock in tumorigenesis and summarizes underlying mechanisms in the clock and its carcinogenic mechanisms, highlighting advances in chronotherapy for cancer treatment.

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