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Cross-talk between the circadian clock and the cell cycle in cancer
Interactions Between the Body’s Daily Clock and Cell Growth in Cancer
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Abstract
Circadian rhythm disruptions are linked to cancer development and progression.
- Genetic changes or unhealthy lifestyles may disrupt circadian homeostasis.
- Disruption of circadian rhythms is associated with severe dysfunctions and pathologies, including cancer.
- The cell cycle, cell growth, and cell death are influenced by the circadian clock.
- Cell cycle machinery and circadian clocks share similar regulatory mechanisms involving gene and protein feedback loops.
- Circadian rhythmicity of specific genes may connect to neoplastic transformations.
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