Glucocorticoids and circadian clock control of cell proliferation: At the interface between three dynamic systems

Glucocorticoids are released in a pulsatile manner that is modulated by the circadian clock.

• The circadian clock regulates daily rhythms in the release of glucocorticoids, which are hormones involved in various physiological processes.
• Glucocorticoid release is influenced by both the brain's circadian pacemaker and the adrenal gland's own internal clock.
• Cell proliferation, which is also regulated by the circadian clock, may be influenced by glucocorticoid signaling.
• The interaction between the circadian clock, glucocorticoids, and cell proliferation involves complex dynamic processes.

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