Modeling circadian clock–cell cycle interaction effects on cell population growth rates

The growth rate of proliferating cells can increase when the cell cycle is coupled to the circadian clock through the protein WEE1.

• The cell cycle can synchronize with the circadian clock, exhibiting various patterns of interaction.
• Growth rates increase for cell cycles with autonomous periods around 24 hours and above 48 hours.
• Mutations in circadian genes can significantly affect cell growth rates, with specific mutations leading to either decreases or increases in proliferation.
• Cry 1 and Cry 2 mutations are associated with decreased growth rates, while Per 2 mutation is linked to enhanced growth.
• Bmal 1 knockout increases growth for cell cycles shorter than 21 hours but decreases it for longer cycles.

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