Full text is available at the source.
Circadian clocks, epigenetics, and cancer
How body clocks and gene regulation relate to cancer
AI simplified
Abstract
The circadian clock may influence cancer survival and proliferation pathways.
- Shift work is linked to increased cancer incidence, suggesting a relationship with circadian rhythms.
- Circadian rhythms may regulate the cell cycle and control cell proliferation.
- The circadian clock operates as a transcriptional system that is regulated at the epigenetic level.
- Cancer cells show differences in histone modifications, DNA methylation, and small regulatory RNAs compared to normal cells.
- Epigenetic control may connect circadian rhythms with tumor initiation or progression, though evidence remains limited.
AI simplified