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How body clocks and gene regulation relate to cancer
Updated
Abstract
The circadian clock may influence cancer survival and proliferation pathways.
- Shift work is linked to increased cancer incidence, suggesting a relationship with circadian rhythms.
- Circadian rhythms may regulate the cell cycle and control cell proliferation.
- The circadian clock operates as a transcriptional system that is regulated at the epigenetic level.
- Cancer cells show differences in histone modifications, DNA methylation, and small regulatory RNAs compared to normal cells.
- Epigenetic control may connect circadian rhythms with tumor initiation or progression, though evidence remains limited.
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