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Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription
How DNA Packaging and Daily Rhythms Organize Clock Gene Activity in Space and Time
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Abstract
Circadian rhythms drive physiological and behavioral functions in ∼24-h cycles through complex gene expression programs.
- Mammalian molecular clock machinery consists of interconnected feedback loops that regulate thousands of genes in a tissue-specific manner.
- Chromatin remodelers contribute to circadian transcriptional control by enabling appropriate epigenomic oscillations.
- Circadian interactomes act as nuclear 'hubs' where genes associated with the circadian cycle physically interact in a specific manner.
- A circadian nuclear landscape may influence metabolic pathways and clock regulators to produce distinct transcriptional programs.
- Understanding the links between the circadian clock machinery and the nuclear landscape could uncover new pathways connecting metabolism to epigenetic regulation.
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