The circadian epigenome: how metabolism talks to chromatin remodeling

Feb 7, 2013Current opinion in cell biology

How Daily Body Rhythms Link Metabolism to DNA Structure Changes

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Abstract

Circadian rhythms govern a variety of physiological and metabolic functions with a 24-hour periodicity.

  • Circadian rhythms are linked to metabolic pathways and can influence the development of metabolic diseases.
  • The molecular clock machinery plays a role in establishing a circadian epigenome that responds to metabolic signals.
  • Impairment of circadian rhythms may lead to disruptions in metabolic control.
  • Pharmacological modulation of circadian rhythms could offer potential treatment options for metabolic and sleep disorders.

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