The circadian clock: a framework linking metabolism, epigenetics and neuronal function

Nov 29, 2012Nature reviews. Neuroscience

The body’s internal clock connecting metabolism, gene regulation, and brain cell activity

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Abstract

Changes in cellular metabolic states may influence circadian rhythms and neuronal function.

  • The circadian clock machinery coordinates biological timekeeping across systems.
  • Peripheral clocks are synchronized by output cues from the central clock system.
  • Alterations in cellular metabolism could affect circadian rhythms and related neuronal activity.
  • Epigenetic control is suggested to play a role in biological timekeeping.
  • There appears to be a close relationship between cellular metabolism and epigenetic state.

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