The body’s internal clock connecting metabolism, gene regulation, and brain cell activity

Changes in cellular metabolic states may influence circadian rhythms and neuronal function.

• The circadian clock machinery coordinates biological timekeeping across systems.
• Peripheral clocks are synchronized by output cues from the central clock system.
• Alterations in cellular metabolism could affect circadian rhythms and related neuronal activity.
• Epigenetic control is suggested to play a role in biological timekeeping.
• There appears to be a close relationship between cellular metabolism and epigenetic state.

Simplified