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Abstract
Lipid nanoparticles (LNPs) influence therapeutic outcomes by forming a biomolecular corona that alters their biological interactions.
- The biomolecular corona, formed by biomolecules in biological fluids, significantly changes the properties of LNPs.
- This corona affects key biological processes such as how LNPs are taken up by cells, recognized by the immune system, and distributed within the body.
- The composition of the corona is influenced by both the inherent characteristics of the LNPs and the surrounding biological environment.
- Understanding the role of the corona is crucial for predicting clinical outcomes based on preclinical data.
- Strategies to alter the corona's composition may enhance the delivery and therapeutic effectiveness of LNPs.
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