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BMAL1 but not CLOCK is associated with monochromatic green light-induced circadian rhythm of melatonin in chick pinealocytes
BMAL1, but not CLOCK, is linked to green lightβs control of melatonin rhythms in chick pineal cells
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Abstract
Knockdown of BMAL1 disrupted circadian rhythms of secretion in chick pinealocytes.
- Monochromatic green light increased melatonin secretion and expression of specific clock genes in chick pinealocytes.
- Si-BMAL1 interference led to the loss of circadian rhythms for AANAT and melatonin, affecting most clock genes except CRY1.
- Overexpressing BMAL1 also disrupted AANAT and melatonin rhythms and caused abnormal expression of BMAL1 and CRY1/2.
- CLOCK overexpression did not affect AANAT, melatonin, or BMAL1 rhythms but altered the rhythms of other clock genes.
- CRY2 expression levels were modified by both knockdown and overexpression of BMAL1, suggesting its involvement in the BMAL1 pathway.
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