Daily differential expression of melatonin‐related genes and clock genes in rat cumulus–oocyte complex: changes after pinealectomy

Mar 27, 2015Journal of pineal research

Daily changes in melatonin and clock gene activity in rat egg-supporting cells before and after removal of the pineal gland

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Abstract

mRNA expression of melatonin-related genes and clock genes in rat cumulus-oocyte complexes varies with the maturational stage of the meiotic cellular cycle and the hour of the day.

  • In immature ovaries, higher mRNA expression levels of Asmt, Mt2, Clock, Bmal1, Per2, and Cry1 are observed in oocytes compared to mature ovaries.
  • Cumulus cells show similar patterns of mRNA expression for Asmt, Aanat, Rorα, Clock, Per1, Cry1, and Cry2 genes between immature and mature ovaries.
  • Pinealectomy alters daily mRNA expression profiles of melatonin and clock-related genes in both oocytes and cumulus cells.
  • Melatonin treatment can partially or completely restore daily mRNA expression profiles of most studied genes.
  • These findings suggest that circulating pineal melatonin is important for regulating daily mRNA expression in cumulus-oocyte complexes.

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