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The Absence of Pineal Melatonin Abolishes the Daily Rhythm of Tph1 (Tryptophan Hydroxylase 1), Asmt (Acetylserotonin O-Methyltransferase), and Aanat (Aralkylamine N-Acetyltransferase) mRNA Expressions in Rat Testes
Lack of Pineal Melatonin Removes Daily Rhythm of Key Melatonin-Making Genes in Rat Testes
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Abstract
Pinealectomy in Wistar rats abolished 24-hour rhythmicity in the mRNA expression of several key genes related to melatonin and steroid production.
- Control rats exhibited daily rhythms in mRNA expression for melatonin-related genes, peaking during the dark phase.
- Pinealectomy disrupted the normal patterns of mRNA expression for multiple genes, shifting peak times to the light phase.
- Melatonin replacement therapy restored normal expression patterns for some genes, including Lhr, Rev-erbĪ±, and Per1, but not for Mt1.
- Significant daytime differences were observed for several steroidogenic and clock genes in control animals, indicating their potential regulation by circadian rhythms.
- The findings suggest that gene expression related to melatonin is likely influenced by the presence of pineal melatonin.
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