Gene

Reducing BMAL1 increases cell death and lowers testosterone production in Leydig cells

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

BMAL1 knockdown in TM3 Leydig cells promoted apoptosis and reduced testosterone secretion.

  • Inhibiting BMAL1 expression increased the levels of BAX mRNA and protein.
  • Knockdown of BMAL1 decreased BCL-2 mRNA and protein expression.
  • Testosterone secretion was significantly reduced following BMAL1 inhibition.
  • Key genes involved in hormone synthesis, such as STAR, CYP11A1, and 3β-HSD, were less expressed after BMAL1 knockdown.
  • Reduced expression of phosphorylated p85 and AKT was observed, suggesting a link to the PI3K/AKT signaling pathway.

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Competing interests

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
PubMed

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