Body clock genes may link fenvalerate exposure to lower testosterone production in mouse testicle cells

Fenvalerate treatment disrupted testosterone synthesis in TM3 cells by altering core clock genes and calcium levels.

• Treatment with Fenvalerate led to changes in the circadian rhythmicity of core clock genes, including Bmal1, Rev-erbα, and Rorα.
• Disruptions in testosterone synthesis were associated with increased intracellular calcium levels.
• Modified expression of steroidogenic acute regulatory (StAR) mRNA was observed following Fenvalerate treatment.
• The findings suggest that Fenvalerate may impair testosterone production through pathways involving clock genes and calcium signaling.

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