Circadian clock and steroidogenic-related gene expression profiles in mouse Leydig cells following dexamethasone stimulation

Dec 28, 2016Biochemical and biophysical research communications

Daily rhythm and hormone-related gene activity in mouse male hormone cells after dexamethasone treatment

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

A lack of circadian rhythmicity was confirmed in mouse testes compared to the robust cycling of circadian clock genes in mouse livers.

  • Immunofluorescence imaging indicated that the BMAL1 protein is exclusively expressed in mouse Leydig cells.
  • Dexamethasone treatment synchronized the expression of several circadian clock and steroidogenic-related genes.
  • Bioinformatic analyses identified circadian clock-related sequence motifs in the promoters of steroidogenic-related genes.
  • Results suggest that mouse Leydig cells may contain a functional circadian oscillator.
  • The circadian clock in mouse Leydig cells may regulate steroidogenic-related gene transcription through specific binding motifs.

AI simplified

Full Text

Full text is available at the source.
View full text (XML) ↗View full text ↗

Related papers

Feb '21
The body clock gene BMAL1 helps control testosterone production by managing hormone-making genes in goat testicle cells
cited by 42 papers
research support, non-u.s. gov't
Oct '17
Body clock genes may link fenvalerate exposure to lower testosterone production in mouse testicle cells
cited by 18 papers
research support, non-u.s. gov't
Jul '11
Rat eye light-sensing clock depends heavily on lighting conditions
cited by 32 papers
research support, non-u.s. gov't
Aug '21
Daily rhythms in fat-carrying protein genes influence testosterone levels in mouse testis
top 30% journal
cited by 25 papers
journal article
May '16
A Daily Biological Clock in the Hearing Midbrain and How Noise Exposure Disrupts It
top 5% journal
cited by 48 papers
research support, n.i.h., extramural
Nov '20
Zearalenone disrupts the body’s internal clock and reduces testosterone production in mouse testicular cells
cited by 30 papers
research support, non-u.s. gov't
Dec '13
Testosterone's role in the internal clock of rat prostate support cells
top 20% journal
cited by 20 papers
research support, non-u.s. gov't
Oct '04
Daily rhythms of key clock genes in mouse body tissues
cited by 256 papers
research support, non-u.s. gov't
Sep '15
Mitomycin C changes daily rhythms of a clock gene by reducing stress hormone signals in mouse cells
top 30% journal
cited by 6 papers
research support, non-u.s. gov't
Dec '15
Discovery of a new daily rhythm regulator that controls BMAL1 levels through a specific gene response element
top 30% journal
cited by 35 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #35
Bacteria exposure resets your internal clock independently of immune responses
2 days ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
1 week ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
2 weeks ago7 studies
issue #32
Bright light preference disrupts mouse sleep patterns even without human lifestyle factors
3 weeks ago7 studies
issue #31
Artificial light at night disrupts bird sleep and metabolism across 675 studies
4 weeks ago7 studies
issue #30
Your hair can reveal your circadian rhythm from a single sample
5 weeks ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
6 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
7 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
8 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief