Full text is available at the source.
Zearalenone perturbs the circadian clock and inhibits testosterone synthesis in mouse Leydig cells
Zearalenone disrupts the body’s internal clock and reduces testosterone production in mouse testicular cells
AI simplified
Abstract
Zearalenone (ZEA) significantly reduced serum testosterone levels in male mice after one week of exposure.
- ZEA disrupted the transcription of core clock and steroidogenic genes in Leydig cells.
- Protein levels of BMAL1, NR1D1, and StAR decreased in response to ZEA exposure.
- ZEA suppressed testosterone secretion from Leydig cells.
- In primary Leydig cells from genetically modified mice, ZEA altered circadian rhythms, resulting in diminished amplitude and phase shifts.
- Reduced expression of core clock and steroidogenic genes was observed in the testes of mice exposed to ZEA.
AI simplified