Molecular and cellular endocrinology

Stress hormones change the timing and hormone production in testis Leydig cells

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

In the first 24 hours after a stress event, testosterone levels decreased while blood corticosterone levels increased.

  • Testosterone and corticosterone levels showed daily variation, with their lowest ratio occurring at the end of the stress session.
  • Stress inhibited the expression of genes related to testosterone production in Leydig cells.
  • Circadian activity of clock genes changed, with increased levels of certain genes and decreased levels of others following stress.
  • A similar hormonal response was observed in glucocorticoid-treated rats.
  • Principal-component-analysis revealed no significant differences between treatments in specific clock genes.
  • Stress may influence the circadian rhythm in Leydig cells through glucocorticoid signaling.

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