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Stress-induced glucocorticoids alter the Leydig cells' timing and steroidogenesis-related systems
Stress hormones change the timing and hormone production in testis Leydig cells
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Abstract
In the first 24 hours after a stress event, testosterone levels decreased while blood corticosterone levels increased.
- Testosterone and corticosterone levels showed daily variation, with their lowest ratio occurring at the end of the stress session.
- Stress inhibited the expression of genes related to testosterone production in Leydig cells.
- Circadian activity of clock genes changed, with increased levels of certain genes and decreased levels of others following stress.
- A similar hormonal response was observed in glucocorticoid-treated rats.
- Principal-component-analysis revealed no significant differences between treatments in specific clock genes.
- Stress may influence the circadian rhythm in Leydig cells through glucocorticoid signaling.
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