The biological function of BMAL1 in skeleton development and disorders

Apr 7, 2020Life sciences

BMAL1’s role in bone growth and bone diseases

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Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Loss of BMAL1 can inhibit bone and cartilage development and lead to abnormal bone mass.

  • BMAL1 is essential for the proper development of hard tissues, including bone, cartilage, and teeth.
  • Defects in BMAL1 within mesenchymal cells can hinder the differentiation of cells that form bone and cartilage.
  • Inactivation of BMAL1 may increase the formation of osteoclasts, which are responsible for bone resorption.
  • Abnormal BMAL1 expression is linked to skeletal disorders such as mandibular hypoplasia, osteoarthritis, and osteoporosis.
  • The review discusses BMAL1's role in skeletal development and homeostasis and explores potential new therapies for bone disorders.

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