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Bone Resorption Is Regulated by Circadian Clock in Osteoblasts
Bone Breakdown Is Controlled by the Daily Clock in Bone-Forming Cells
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Abstract
Global deletion of murine Bmal1 led to low bone mass and increased bone resorption.
- The Clock system in osteoblasts may regulate bone mass and resorption.
- Oscillatory rhythmic expression of Bmal1 and Per1 was observed in the bone in vivo and in cultured osteoblasts.
- Bmal1-deficient osteoblasts demonstrated an increased capacity to support the formation of bone-resorbing cells called osteoclasts.
- Deletion of Bmal1 in osteoblasts alone was sufficient to replicate the low bone mass phenotype.
- 1α,25-dihydroxyvitamin D enhanced Rankl expression more strongly in Bmal1-deficient conditions.
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