The brain's master circadian clock: Implications and opportunities for therapy of sleep disorders

The suprachiasmatic nuclei (SCN) maintain a near-24-h rhythm of electrical activity independently of environmental cues.

• The circadian rhythm in the SCN is driven by intrinsic molecular mechanisms within its neurons.
• The SCN is influenced by various factors, including glutamate, PACAP, melatonin, and neuropeptide Y.
• Environmental cues such as light and social activities can affect the SCN's function.
• The SCN regulates several physiological and behavioral functions, including attention, body temperature, and the sleep-wake cycle.
• Dysregulation of the SCN-linked sleep-wake cycle may contribute to sleep disorders like insomnia.

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