Full text is available at the source.
Reciprocal Regulation of Brain and Muscle Arnt-Like Protein 1 and Peroxisome Proliferator-Activated Receptor α Defines a Novel Positive Feedback Loop in the Rodent Liver Circadian Clock
Brain and muscle proteins control each other to create a feedback loop in the daily liver clock of rodents
AI simplified
Abstract
PPARalpha is required to maintain the circadian rhythm of the master clock gene bmal1 in vivo.
- PPARalpha influences both central and peripheral circadian control mechanisms.
- It directly binds to a specific region in the promoter of the bmal1 gene.
- BMAL1 acts as an upstream regulator of PPARalpha gene expression.
- Fenofibrate can induce a circadian rhythm of clock gene expression in cell culture.
- Fenofibrate also up-regulates hepatic bmal1 levels in vivo.
- Findings suggest a regulatory feedback loop between BMAL1 and PPARalpha in peripheral clocks.
AI simplified