Brain and muscle proteins control each other to create a feedback loop in the daily liver clock of rodents

PPARalpha is required to maintain the circadian rhythm of the master clock gene bmal1 in vivo.

• PPARalpha influences both central and peripheral circadian control mechanisms.
• It directly binds to a specific region in the promoter of the bmal1 gene.
• BMAL1 acts as an upstream regulator of PPARalpha gene expression.
• Fenofibrate can induce a circadian rhythm of clock gene expression in cell culture.
• Fenofibrate also up-regulates hepatic bmal1 levels in vivo.
• Findings suggest a regulatory feedback loop between BMAL1 and PPARalpha in peripheral clocks.

Simplified