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A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function
The mouse CLOCK protein may not be needed for the body’s internal daily rhythm
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Abstract
CLOCK-deficient mice continue to exhibit robust circadian rhythms despite the absence of CLOCK.
- Circadian rhythms in locomotor activity are maintained in CLOCK-deficient mice.
- These mice show altered light responses compared to normal mice.
- Changes in clock gene mRNA and protein levels are observed in both the suprachiasmatic nuclei and liver.
- Molecular feedback loops remain functional in CLOCK-deficient animals.
- Findings challenge the idea that CLOCK:BMAL1 heterodimers are essential for circadian clock function.
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