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Differential maturation of circadian rhythms in clock gene proteins in the suprachiasmatic nucleus and the pars tuberalis during mouse ontogeny
Different Development Timing of Daily Rhythm Proteins in the Brain's Master Clock and Hormone-Regulating Area in Mice
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Abstract
In the foetal suprachiasmatic nucleus (SCN), levels of clock proteins were significantly lower than adult levels except for BMAL1.
- The SCN functions as a master pacemaker that coordinates circadian rhythms in mammals.
- Clock proteins in the SCN undergo ontogenetic maturation, with the foetal stage showing lower levels compared to adults.
- By the infant stage, clock protein levels in the SCN reach those similar to adults.
- The pars tuberalis (PT) exhibits consistent clock protein levels across different ontogenetic stages, influenced by maternal melatonin.
- Maternal melatonin may play a crucial role in establishing circadian rhythms in the foetal PT, as the foetal pineal gland cannot produce melatonin yet.
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