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CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock
Similar Roles of CLOCK and NPAS2 Proteins in the Brain’s Daily Rhythm Control Center
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Abstract
CLOCK-deficient mice continue to exhibit robust behavioral and molecular rhythms.
- NPAS2 can functionally replace CLOCK in the master brain clock.
- Both NPAS2 and CLOCK are transcription factors that regulate circadian rhythms.
- The study suggests alternative pathways may exist for maintaining circadian rhythms in mammals.
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