Similar Roles of CLOCK and NPAS2 Proteins in the Brain’s Daily Rhythm Control Center

CLOCK-deficient mice continue to exhibit robust behavioral and molecular rhythms.

• NPAS2 can functionally replace CLOCK in the master brain clock.
• Both NPAS2 and CLOCK are transcription factors that regulate circadian rhythms.
• The study suggests alternative pathways may exist for maintaining circadian rhythms in mammals.

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