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Lost rhythms: Breast cancer hijacks neuronal circuits that blunt GC rhythms to promote tumor progression
Breast cancer disrupts brain circuits that control daily hormone rhythms to help tumors grow
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Abstract
Breast cancer is associated with disrupted diurnal glucocorticoid oscillations.
- Cancer may disinhibit hypothalamic CRH neurons, affecting hormonal rhythms.
- Time-specific neuromodulation could restore these rhythms.
- Restoring rhythms may enhance CD8 T cell functions.
- This mechanism suggests potential targets for chronotherapy in cancer treatment.
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