Contribution of calcium-sensitive potassium channels to NS1619-induced relaxation in human pregnant myometrium

Mar 25, 1998Human reproduction (Oxford, England)

Role of calcium-activated potassium channels in relaxing pregnant human uterine muscle with NS1619

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Circadian BiologyCircadian Biology on OpenScience ā†—PubMed ā†—DOI ā†—

Abstract

NS1619 produces a potent relaxant effect on the pregnant human myometrium.

  • Large-conductance, calcium-sensitive potassium channels (BK(Ca)) are present in high density in the pregnant human myometrium.
  • Isometric tension experiments indicate that NS1619 effectively relaxes the myometrium.
  • Patch-clamp techniques suggest that NS1619 directly stimulates BK(Ca) channel activity, increasing the time these channels remain open.
  • The BK(Ca) channel may serve as a potential target for drug intervention in conditions like failure to labour, preterm labour, or dysmenorrhoea.

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