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Pinacidil activates large potassium channels in pregnant human uterine muscle
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Abstract
Pinacidil induced relaxation of myometrial strips at a half maximal response concentration of 0.4 +/- 0.1 micromol/L.
- Pinacidil's relaxation effect on pregnant nonlabor human myometrial strips was significantly inhibited by 500 nmol/L charybdotoxin.
- Application of 10 micromol/L glibenclamide also impaired pinacidil-induced relaxation.
- Coapplication of charybdotoxin and glibenclamide produced a biphasic response curve, with half maximal response concentrations of 0.6 +/- 0.2 micromol/L and 189.7 +/- 0.8 micromol/L.
- Pinacidil dramatically increased large-conductance calcium-dependent potassium channel activity, requiring calcium ions at the intracellular membrane.
- Charybdotoxin, but not glibenclamide, blocked the pinacidil-induced activity of large-conductance calcium-dependent potassium channels.
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