Carbohydrate ingestion prior to exercise augments the exercise-induced activation of the pyruvate dehydrogenase complex in human skeletal muscle.
Eating carbohydrates before exercise increases activation of the muscle energy enzyme during exercise
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Abstract
Muscle PDC activity was higher at the end of exercise in the CHO trial compared to the CON trial, with values of 1.78±0.18 and 1.27±0.16 mmol min(-1) (kg wet matter)(-1), respectively.
- Pre-exercise carbohydrate ingestion is associated with increased muscle PDC activation during exercise.
- Lower acetylcarnitine concentrations were observed in the CHO trial compared to the CON trial (7.1±1.2 vs. 9.1±1.1 mmol kg(-1) dry matter(-1)).
- Citrate concentrations were also reduced in the CHO trial compared to the CON trial (0.73±0.05 vs. 0.91±0.10 mmol (kg dry matter)(-1)).
- No significant differences were found in the rates of muscle glycogen and phosphocreatine breakdown or lactate accumulation between trials.
- These findings suggest that while CHO ingestion enhances PDC activation and alters certain metabolite levels, it does not impact ATP resynthesis via substrate level phosphorylation.
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