Higher Adherence to Cardioprotective Diet is Associated with Reduced Risk of Enterotomy and All-Cause Mortality among 5549 Individuals with Inflammatory Bowel Disease in a Prospective Cohort Study

Jun 24, 2023The Journal of nutrition

Following a Heart-Healthy Diet Linked to Lower Risk of Intestinal Surgery and Death in People with Inflammatory Bowel Disease

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Abstract

Among 5549 participants with inflammatory bowel disease, those adhering to a cardioprotective diet exhibited a 60% lower risk of enterotomy compared to those with the lowest adherence.

Participants with the highest adherence to the cardioprotective diet (scores 5-7) had a lower risk of all-cause mortality (hazard ratio: 0.77) compared to those with the lowest adherence (scores 0-2).
A total of 506 enterotomy events and 566 deaths were documented during an average follow-up of 12.0 years.
Increased adherence to the cardioprotective diet is associated with improved outcomes in individuals with inflammatory bowel disease.

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BACKGROUND: The cardioprotective diet has been previously reported to be inversely associated with the development of inflammatory bowel disease (IBD), but whether it is beneficial to improve adverse outcomes in IBD remains unknown.

OBJECTIVES: We aimed to investigate whether the cardioprotective diet is associated with enterotomy and all-cause mortality among individuals with IBD.

METHODS: We conducted a prospective cohort study of 5549 participants with IBD from the UK Biobank. Cardioprotective diet scores (range 0-7) were calculated based on the consumption of 7 common food groups collected by a validated food frequency questionnaire. Outcomes of interest were enterotomy and all-cause mortality, ascertained via inpatient data and death registry, respectively. Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

RESULTS: During an average follow-up duration of 12.0 y, we documented 506 enterotomy and 566 death events. Compared with participants with the lowest adherence to the cardioprotective diet (score of 0-2), participants with the highest adherence to the cardioprotective diet (score of 5-7) were observed to have a lower risk of enterotomy (HR: 0.60; 95% CI: 0.47, 0.76; P < 0.001; P-trend < 0.001) and all-cause mortality (HR: 0.77; 95% CI: 0.61, 0.98; P = 0.031; P-trend = 0.025).

CONCLUSIONS: A greater adherence to the cardioprotective diet is associated with a lower risk of enterotomy and all-cause mortality among individuals with IBD.

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Higher Adherence to Cardioprotective Diet is Associated with Reduced Risk of Enterotomy and All-Cause Mortality among 5549 Individuals with Inflammatory Bowel Disease in a Prospective Cohort Study

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