Higher Dietary Quercetin Intake Is Associated with Lower Risk of Adverse Outcomes among Individuals with Inflammatory Bowel Disease in a Prospective Cohort Study

Higher dietary intake of quercetin is associated with a lower risk of enterotomy and all-cause mortality in individuals with inflammatory bowel diseases (IBD).

• In a cohort of 2293 participants with IBD, 193 enterotomy events and 176 deaths were recorded over a mean follow-up of 9.6 years.
• Individuals in the highest quartiles of quercetin intake had a lower risk of enterotomy (HR: 0.46; 95% CI: 0.28, 0.76) compared to those in the lowest quartile.
• The association between higher quercetin intake and reduced risk of enterotomy was consistent in patients with Crohn's disease (HR: 0.30; 95% CI: 0.12, 0.78) but not in those with ulcerative colitis (HR: 0.58; 95% CI: 0.32, 1.07).
• Higher quercetin intake was linked to a lower risk of all-cause mortality (HR: 0.53; 95% CI: 0.33, 0.83) in the overall IBD cohort.
• This inverse association with mortality was consistent in Crohn's disease (HR: 0.37; 95% CI: 0.15, 0.92) and ulcerative colitis (HR: 0.55; 95% CI: 0.31, 0.95).

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