Higher dietary fibre intake is associated with lower risk of inflammatory bowel disease: prospective cohort study

Jul 19, 2023Alimentary pharmacology & therapeutics

Higher fiber in diet is linked to lower risk of inflammatory bowel disease

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Abstract

During an average follow-up of 12.1 years, 1,473 incident IBD cases were identified among 470,669 participants.

An inverse association was observed between dietary fibre intake and the risk of inflammatory bowel disease (IBD) and Crohn's disease (CD).
Higher dietary fibre intake was associated with a hazard ratio of 0.74 for IBD and 0.48 for CD when comparing the lowest quintiles.
No significant association was found between dietary fibre intake and ulcerative colitis (UC), with a hazard ratio of 0.92.
Specific sources of dietary fibre, such as fruit and bread, were linked to a decreased risk of CD, while cereal intake was associated with a lower risk of UC.

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BACKGROUND: Limited prospective studies that have examined the association of dietary fibre with IBD have provided inconsistent evidence.

AIM: To examine any associations between dietary fibre intake and subsequent incidence of IBD, Crohn's disease (CD) and ulcerative colitis (UC) METHODS: We conducted a prospective cohort study of 470,669 participants from the UK Biobank and estimated dietary fibre intake from a valid food frequency questionnaire at baseline. Incident IBD was ascertained from primary care data and inpatient data. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between dietary fibre intake and the risk of IBD, CD and UC.

RESULTS: During an average follow-up of 12.1 years, we ascertained 1473 incident IBD cases, including 543 cases of CD and 939 cases of UC. Comparing the lowest quintiles, an inverse association was observed between dietary fibre intake and risk of IBD (HR 0.74, 95% CI 0.58-0.93, p = 0.011) and CD (HR 0.48, 95% CI 0.32-0.72, p < 0.001), but not UC (HR 0.92, 95% CI 0.69-1.24, p = 0.595). For specified sources, dietary fibre intake from fruit and bread decreased the risk of CD, while dietary fibre intake from cereal decreased the risk of UC.

CONCLUSIONS: Higher consumption of dietary fibre was associated with a lower risk of IBD and CD, but not UC. Our findings support current recommendations to increase the intake of dietary fibre.

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Higher dietary fibre intake is associated with lower risk of inflammatory bowel disease: prospective cohort study

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