Dietary quercetin intake is associated with lower ulcerative colitis risk but not Crohn's disease in a prospective cohort study and in vivo experiments

Among 187,709 participants, higher quercetin intake was associated with a lower risk of inflammatory bowel disease (IBD).

• Participants in the highest quintiles of quercetin intake had an adjusted hazard ratio of 0.76 for IBD compared to those in the lowest quintile.
• For ulcerative colitis, the adjusted hazard ratio was 0.69, indicating a significant association with higher quercetin intake.
• No significant association was found between quercetin intake and Crohn's disease, with an adjusted hazard ratio of 0.95.
• In mouse models, pre-treatment with quercetin appeared to reduce the severity of chemically induced colitis.
• The findings suggest that quercetin may play a protective role against IBD in humans and highlight the need for further research.

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