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Non-alcoholic fatty liver degree and long-term risk of incident inflammatory bowel disease: A large-scale prospective cohort study
Fatty liver levels and long-term risk of developing inflammatory bowel disease in a large population
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Abstract
Among 418,721 participants, 38.40% were diagnosed with (NAFLD) at baseline.
- A higher degree of non-alcoholic fatty liver is associated with a 36% increased risk of developing (IBD).
- The highest quartile of fatty liver index (FLI) shows a 25% higher risk of ulcerative colitis (UC) compared to the lowest quartile.
- The risk of Crohn's disease (CD) is 58% higher in individuals with the highest quartile of FLI than those in the lowest quartile.
- Participants with NAFLD have a 13% increased risk of incident IBD compared to those without NAFLD.
- The risk of CD is 36% higher in individuals diagnosed with NAFLD.
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Key numbers
1.36
Increase in risk
Hazard Ratio for highest vs. lowest FLI quartile
1.13
risk increase
Hazard Ratio comparing vs. non- participants
1.36
Increase in CD risk
Hazard Ratio for participants regarding CD