Blood Metabolite Patterns Linked to the EAT-Lancet Diet and Risk of Inflammatory Bowel Disease

Over a mean follow-up of 13.15 years, 571 cases of Crohn's disease and 1066 cases of ulcerative colitis were recorded among 187,558 participants.

• A one-point increase in the EAT-Lancet diet score is associated with a 5% reduction in the risk of inflammatory bowel disease.
• The hazard ratio for ulcerative colitis per one-point increase in the EAT-Lancet score is 0.95, indicating a potential protective effect.
• The hazard ratio for Crohn's disease per one-point increase in the EAT-Lancet score is 0.93, suggesting a similar trend.
• Seven metabolites were identified as mediators of the association between the EAT-Lancet diet and IBD risk, accounting for 10.7% of the association.
• Greater adherence to the EAT-Lancet diet may be linked to a reduced risk of developing inflammatory bowel disease.

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