Frontiers in endocrinology

Heart health outcomes of SGLT2 inhibitors compared to GLP-1 receptor agonists in type 2 diabetes patients with past heart attacks

Updated

Abstract

A systematic review and network meta-analysis was conducted to compare cardiovascular efficacy in patients with type 2 diabetes and a history of myocardial infarction.

  • Patients with type 2 diabetes and a history of myocardial infarction have a high risk of recurrent cardiovascular events.
  • Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are associated with reduced cardiovascular risk.
  • Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may also reduce cardiovascular risk.
  • No direct head-to-head trials have been conducted to compare the cardiovascular efficacy of SGLT2i and GLP-1 RAs.

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